Web7 mrt. 2024 · In cancers, KIF18A is central to the proliferation of chromosomally unstable tumor cells. Disrupting the action of this protein could interrupt the process of cell division … Web23 okt. 2024 · Kif19A is a motile MT depolymerase involved in cilia length control ( 16 ). Several studies have shown that human Kif18A is associated with invasive breast …
Frontiers Prognostic Biomarker KIF18A and Its Correlations With ...
Web15 jun. 2024 · KIF18A is overexpressed in a subset of human cancers, and its elevated expression is associated with tumor aggressiveness. Chromosomal instability (CIN) is a hallmark of human cancers and is... Web7 mrt. 2024 · “We are excited to add sovilnesib to our growing pipeline of CIN-targeted therapeutics which includes our own KIF18A inhibitor, VLS-1488,” said Charles Hugh-Jones, Chief Executive Officer at Volastra. “Our focus is helping patients in critical need of new treatment options,” added Scott Drutman MD PhD, Chief Medical Officer. kfc and russia
Novel KIF18A Inhibitors for Treating Cancer - ACS Publications
Web6 apr. 2024 · Notably, the expression of kinesin-8 is often dysregulated in cancer and therefore may play an important role in that process. Interestingly, overexpression of KIF18A was reported to promote tumour formation, invasion and metastasis in colorectal cancer, while its knockdown triggered proliferation decrease in cancer cell lines, altogether … Web22 feb. 2024 · KIF18A is required for proliferation of CIN cells derived from triple negative breast cancer or colorectal cancer tumors but is not required in near-diploid cells. Following KIF18A... Web7 mrt. 2024 · NEW YORK, March 7, 2024 – Volastra Therapeutics, a clinical stage cancer biotechnology company focused on exploiting chromosomal instability (CIN), today … kfc and nutrition