Shared eqtl

Author: xeoc

August undefined, 2024

Webbsion QTL (eQTL) mapping data from immortalized lymphocytes. They found a signiﬁcant and replicated enrichment of GWAS associationsamong the top-ranked eQTLs, despite the fact that no single variant achieved genome-wide signiﬁcance in the original GWAS [11]. In this study, eQTL and GWAS data were not combined to propose mechanisms for disease- Webb17 mars 2024 · Cis-eQTLs are generally classified as variants that lie within 1 million base pairs of the gene of interest. However, this is indeed an arbitrary cutoff and can be altered by an order of magnitude, for instance. Trans-eQTLs The second distinct type of eQTL is a trans-eQTL (Figure 31.4).

LocusFocus: Web-based colocalization for the annotation and

Webb13 dec. 2011 · Summary: seeQTL is a comprehensive and versatile eQTL database, including various eQTL studies and a meta-analysis of HapMap eQTL information. The … Webb28 juli 2024 · We show evidence for the shared genetic basis of neonatal eQTLs and reQTLs with common autoimmune and allergic diseases, and many of such … ima thomas

Fine mapping spatiotemporal mechanisms of genetic variants …

Webb16 juli 2024 · An expression quantitative trait locus (eQTL) is a genetic locus where sequence variation is associated with altered expression of one or more genes. eQTL … Webb10 aug. 2024 · Background Previous expression quantitative trait loci (eQTL) studies have identified thousands of genetic variants to be associated with gene expression at the mRNA level in the human liver. However, protein expression often correlates poorly with mRNA levels. Thus, protein quantitative trait loci (pQTL) study is required to identify … Webb19 nov. 2024 · 106 P=1.6×10-6, IFNAR2: P=9.8×10-11, and IL-10RB: P=1.9×10-14) using cis-eQTL genetic 107 instruments that also had strong evidence for colocalization with COVID-19 hospitalization. To 108 disentangle the shared eQTL signal for IL10RB and IFNAR2, we conducted phenome-wide imathoessa

Characterization of the transcriptional divergence between the ...

Genomic variants affecting homoeologous gene expression …

WebbAbout Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features NFL Sunday Ticket Press Copyright ... Webb18 jan. 2024 · The ratio of eQTL overlap between tissues depends on the similarity of biological functions, with more similar tissues sharing more eQTL . Our results support the significant overlap of eQTL between liver and muscle [see Additional file 5 : Figure S3], which could be due to the similarity of biological functions that regulate meat traits … im a thotWebb26 jan. 2024 · The discovery of expression quantitative trait loci (eQTLs) and their target genes (eGenes) has not only compensated for the limitations of genome-wide association studies for complex phenotypes but has also provided a basis for predicting gene expression. Efforts have been made to develop analytical methods in statistical genetics, … imat horarios

"Webb17 apr. 2024 · Genome-wide association studies (GWAS) have identified abundant risk loci associated with schizophrenia (SCZ), cardiometabolic disease (CMD) including body mass index, coronary artery diseases, type 2 diabetes, low- and high-density lipoprotein, total cholesterol, and triglycerides. Although recent studies have suggested that genetic risk … " - Shared eqtl

Shared eqtl

Integrative analysis of summary data from GWAS and eQTL …

Webb14 aug. 2024 · The general TWAS framework requires previously estimated cis -eQTLs for all genes in a dataset with both genotype and gene expression measurements. The resulting eQTL effect sizes build a predictive model that can impute gene expression in an independently genotyped population. Webb29 juli 2024 · The lack of shared eQTL between the two brain regions implies that genetic regulation of gene expression appears to be relatively independent between the two brain regions and suggest that coevolution between these two brain regions might be more functionally driven than developmental.

Did you know?

Webb1 aug. 2013 · We next examined the hypothesis that the CRE landscape is a major determinant of eQTL specificity, and found that eQTL SNPs that overlap cell type specific CREs are more likely to be cell type specific than are eQTL SNPs that overlap shared CREs (Fisher's exact test ) for , , and CRE data sets in LCLs, liver, and cerebellum, respectively … Webb23 mars 2024 · Photorespiration is a reoccurring term enriched also in 6_5A30 and 7_5A30), which share an expression bias for the Remus allele. This process does not seem to be retained at 50 hai, as large fractions of the 442 shared eQTL originate from clusters 1_5A30 and 2_5A30. At 50 hai, almost 3000 regulated genes cover a wide variety of …

Webb1 maj 2013 · Between the two environments 401 expression traits had an eQTL in both environments, of which 109 had an eQTL within 20 cM ( Table 1 and Figure 2 ). Of the 109 eQTL with a shared location between environments, 20 were among the 50 most significant eQTL in both environments. Webb27 apr. 2024 · The 386 distinct eGenes in shared eQTL pairs in significant blood and brain results were further examined for differentially expressed genes (DEG) between AD …

Webb2 juni 2024 · Summary-data-based Mendelian Randomization (SMR) addresses this problem through an instrumental variable approach that integrates data from independent GWAS and expression quantitative trait locus (eQTL) studies in order to infer a causal effect of gene expression on a trait. Results Webb1 mars 2014 · Connections among three major expression quantitative trait loci (eQTL) hotspots involved in major seed and seed-specific processes. A network representation depicts interactions among photosynthesis, fatty acid (FA) biosynthesis, oleosin, and other seed-specific genes with shared eQTL depicted separately in Fig. 3.

Webb29 aug. 2024 · We found clusters of eQTL linked to shared functions across tissues and tissue-specific clusters linked to tissue-specific functions, driven by genetic variants with …

Webb20 juli 2024 · An eQTL is commonly viewed as shared between tissues when the same SNP influences a gene in multiple tissues (GTEx Consortium 2015). Alternatively, two eQTLs can be viewed as shared if they influence expression of the same gene in multiple tissues, even though the SNP itself differs between tissues. list of hotel by hiltonWebb9 jan. 2024 · Although most cis -eQTLs were shared between most bulk tissues, the analysis of purified cell types identified a greater diversity of cell-type-specific eQTLs, a … ima thrombusWebb20 juni 2024 · Enrichment for overlap with context-specific eQTL in liver or heart is generally higher than enrichment for significant eQTL overall, but the distribution of shared eQTL remains similar (Fig. 4c, Fig. 5d; Additional file 1: Table S7). Within a context, most eQTL do not overlap an enhancer, and there is wide variation in the number of eQTL ... i-math pte ltdWebb19 maj 2024 · Bulk tissue eQTL is to identify the downstream effects of disease-associated genetic variants on the gene expression measured at the bulk tissue level. Because of the affordable price (compared to a single-cell experiment) and the convenience to get enough volume of RNAs from bulk tissue, bulk RNA-sequencing is still the most widely used … list of hotel developersWebb目前做的最多的就是eQTL，即与基因表达水平的遗传变异。血液是最常用的组织，其他都太难取了。 MolQTL通常分为 (1) 顺式作用，通常定义为1 Mb以内的基因调控；顺式作用通常很大，并且使用小样本量即可轻松发现。 (2) 反式作用，定义为影响基因更远或位于不同染色体上的molQTL。反式效应往往小得多，并且需要更大的样本量。基因转录水平是 … list of hotel managementhttp://zarlab.cs.ucla.edu/tag/ecaviar/ im at houseWebb2 juni 2024 · cis-eQTL data used in this study was derived from a meta-analysis of cis-eQTL’s between independent brain and blood samples . The exact meta-analysis cis … imath python